(P55) MPOX (JYNNEOS) VACCINATION AMONG PEOPLE LIVING WITH HIV IN ALAMEDA COUNTY, CA

Background:
The U.S. mpox outbreak resulted in 58 deaths and most deaths occurred in persons living with HIV (PLWH). Mpox vaccine (JYNNEOS) is a two-dose vaccine series recommended for all PLWH to prevent mpox infection and serious outcomes from disease. We evaluated JYNNEOS vaccination among Alameda County, CA including the City of Berkeley PLWH.

Methods:
For our analysis, PLWH included persons in the enhanced HIV/AIDS reporting system (eHARS) and living in Alameda County, CA as of Dec 31, 2022. We matched PLWH by name and birth date to California Immunization Registry (CAIR) data to assess JYNNEOS vaccination through January 31, 2024. We describe PLWH retained in care as persons who had at least 2 healthcare visits with laboratory tests at least 90 days apart; a chi-square test of significance was used to evaluate the association between retention in care and vaccination.

Results:
Among PLWH, 1,192 (19.2%) received at least one JYNNEOS dose, and among those, 859 (72.0%) received the two-dose vaccine series. Among 1,916 PLWH aged >60 years, 326 (17.0%) received at least one JYNNEOS dose; among 1,015 female PLWH 16 (1.6%) received at least one JYNNEOS dose. At least one JYNNEOS dose was highest (26.8%) among PLWH who reported being men who have sex with men, and lowest (2.7%) among people who used intravenous drugs at HIV diagnosis. Retention in care was significantly associated with at least one JYNNEOS dose (Odds Ratio 4.7, p-value <0.001). Among PLWH retained in care, 25.7% were vaccinated compared with 6.2% of PLWH not retained in care.

Conclusion:
Alameda County public health efforts should include a focus on Mpox (JYNNEOS) vaccination of PLWH, given the potential serious outcomes from mpox infection and overall low (19.2%) vaccination uptake. As noted in this assessment, retention in HIV care provides an effective platform for prevention including mpox vaccination.